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Water resistance of the inner surface of medicinal glass bottles

Although there are many advantages as a medicine packaging glass bottle, there is also a major disadvantage: under certain conditions, the glass flakes are detached from the inner surface of the glass container and directly enter the solution, which is sometimes difficult to detect by the naked eye. Although no adverse events directly related to degaussing have been reported, these glass flakes present in intravenous drugs may cause thrombosis and other vascular events (such as phlebitis); for subcutaneous vaccination, detachment may result in The occurrence of foreign body granuloma, local injection site reaction and increased immunogenicity. Therefore, the experimental equipment for water resistance of the inner surface of medicinal glass bottles is a glass bottle testing instrument commonly used in pharmaceutical laboratory.

Experimental methods for Grinding and smashing:

Grinding and smashing according to YBB00252003-2015 glass granules at 121 ° C water resistance determination and classification, YBB00362004-2015 glass granules at 98 ° C water resistance determination and classification requirements, the particle size of 300-500μm glass particles 2g, in 98 The °C test water should be soaked for 60 minutes. The extent to which the glass particles are etched by water is determined by titration of the etchant and fractionation.

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